Podcast: a16z

In this episode of Web3 with a16z, Shopify CEO and cofounder Tobias Lütke joins a16z cofounder Ben Horowitz for a conversation recorded live at the a16z crypto Founders Summit.

Together, they explore what it takes to build a breakout startup in a competitive market, the changing landscape of retail, and how to drive workplace change while navigating corporate culture and calls for activism.

Tobias shares the story behind Shopify's growth from a snowboarding store to a global ecommerce platform serving millions of merchants, discusses the moral imperative of creating great software, and offers insights on leadership, innovation, and embracing negativity as a tool for progress.

The episode also touches on the intersection of AI and crypto, the power of decentralization, and the next wave of technologies reshaping business and commerce.

Did you know the U.S. nurse labor market is over $600 billion annually, but the dedicated software market for nurses is almost zero?

In this episode General Partners Alex Rampell, David Haber, and Angela Strange discuss how AI is revolutionizing labor by automating tasks traditionally done by humans.

They’ll trace the evolution of cloud eras — from the original to financial services-enabled to the current AI-enabled outcomes era — showcasing how AI is creating unprecedented opportunities, allowing startups to outpace incumbents. They also explore how this shift will reshape industries, where we are in the adoption curve and what companies need to succeed, and the gaps where the a16z Enterprise team would love to see more innovation.

Over half of Americans live in childcare deserts, while 90% of brain development happens before the age of five. All the while, education and childcare remain among the most resistant sectors to technological change. Billions of dollars have been spent, but outcomes continue to lag. Why?

In this episode, we dive into the systemic issues—misaligned incentives, political resistance, and the lack of a shared vision around the purchase of an education. We also explore how technology and entrepreneurial innovation may be shifting the tide.

You’ll hear from Anurupa Ganguly (Prisms), Chris Bennett (Wonderschool), Anna Edwards (Whiteboard Advisors), and a16z General Partner Jeff Jordan discuss the criticality of early childhood education, how public-private partnerships are required for scale, and how we can engage risk-averse decision-makers.

Listen to learn how the next generation can reclaim the American dream.

This episode was originally published on our sister podcast, web3 with a16z. If you’re excited about the next generation of the internet, check out the show: https://link.chtbl.com/hrr_h-XC

We've heard a lot about the premise and the promise of prediction markets for a long time, but they finally hit the main stage with the most recent election. So what worked (and didn't) this time? Are they really better than pollsters, is polling dead?

So in this conversation, we tease apart the hype from the reality of prediction markets, from the recent election to market foundations... going more deeply into the how, why, and where these markets work. We also discuss the design challenges and opportunities (including implications for builders throughout). And we also cover other information aggregation mechanisms -- from peer prediction to others -- given that prediction markets are part of a broader category of information-elicitation and information-aggregation mechanisms.

Where do domain experts, superforecasters, pollsters, and journalists come in (and out)? Where do (and don't) blockchain and crypto technologies come in -- and what specific features (decentralization, transparency, real-time, open source, etc.) matter most, and in what contexts? Finally, we discuss applications for prediction and decision markets -- things we could do right away to in the near-future to sci-fi -- touching on trends like futarchy, AI entering the market, DeSci, and more.

Our special expert guests are Alex Taborrok, professor of economics at George Mason University and Chair in Economics at the Mercatus Center; and Scott Duke Kominers, research partner at a16z crypto, and professor at Harvard Business School -- both in conversation with Sonal Chokshi.

As a reminder: None of the following should be taken as business, investment, legal, or tax advice; please see a16z.com/disclosures for more important information.

Sales is evolving. AI-native systems are replacing traditional CRM tools, capturing unstructured insights from emails, Slack, surveys, and more in real time. These systems automate early-stage tasks like prospecting and qualification, enabling sales teams to focus on high-value work—while AI provides live coaching and drives decisions across sales, marketing, and product teams.
In this episode, a16z partners Joe Schmidt and Marc Andrusko explore the evolution of sales tools and strategies, sharing their insights on what’s driving this shift.
Is this the “Death of a Salesforce”? Perhaps that’s an overstatement. But one thing is clear: the future belongs to those who leverage data and AI to drive decisions—not just activities.

What if the biggest challenge of our time isn’t living longer, but living better?

In this episode, we’re tackling one of humanity’s greatest accomplishments—and perhaps its most overlooked challenge: longevity. As more people live past 100, our systems—healthcare, finance, career planning, and even our cultural perceptions of aging—need a fundamental overhaul.

We’re joined by Dr. Andrew Scott, author of The Longevity Imperative, and Vijay Pande a16z’s Bio & Health general partner, to explore how a shift from “sick care” to “health care” could transform our lives. Together, we discuss the implications of longer lifespans, from the individual choices that can improve our healthspans to the economic and societal shifts required to sustain a healthier, more productive aging society.

Join us as we reimagine the future of aging, where living to 100 can be more than survival—it can be a life well-lived.

America is a country of immense wealth, but our manufacturing infrastructure is struggling to keep pace.

In this episode, we discuss the overlooked crisis of American manufacturing and what it means for our national resilience. a16z’s Oliver Hsu hosts a conversation with founders Jordan Black (Senra Systems), Chris Power (Hadrian), and Bryon Hargis (Castellan) on why we need to revive our industrial base — and fast.

From outdated regulations to the adoption of automation, they break down the “death by a thousand paper cuts” that has left our production capabilities lagging behind. Yet, it’s not all grim: these founders share how their companies are taking bold, vertically integrated approaches to reinvent the sector and reclaim America's industrial edge.

There is a recurring theme that the tech industry is busy cranking out fluffy social apps rather than hardcore technology. Not the case, say Chris Dixon, Benedict Evans and Balaji Srinivasan. Not only are tech entrepreneurs going after the deficienci...

The security landscape is changing. Can companies fight back against an increasingly well-armed and sophisticated set of bad players? “I think it is the beginning of a wakeup call,” former deputy secretary of defense Ashton Carter says. “That said, I...

VCs wouldn't fund Salesforce ("that obviously won't work") when Marc Benioff began. With the cloud a growing part of practically every company, government, organization, and people's lives, a lot's changed since 1999. But what's next? Do enterprise ...

Bitcoin has not been easy for Wall Street and other traditional financial centers to wrap their collective heads around, let alone take seriously. But that has changed recently, argue authors Michael Casey and Paul Vigna in their book The Age of Cryp...

There are great examples of communities helping to grow and solidify online marketplaces. eBay in its early days certainly leveraged the power of community to bring buyers and sellers onto its platform. Today, companies like Etsy, Uber and Airbnb are...

“At a moment of great concern about inequality, now comes a learned tome proclaiming the gravity of the inequality problem,” says Larry Summers in a conversation with Andreessen Horowitz’s Balaji Srinivasan. “It’s a stunning thing, and it must reflec...

People Marketplaces are a lot like eBay -- connecting buyer and seller -- but for services, says a16z General Partner Jeff Jordan. These two-sided marketplaces are cropping up across the economy, from finding a ride to house cleaning and pet sitting...

There is a shift in enterprise hardware from expensive, proprietary hardware to cheap components plucked directly from the consumer hardware supply chain. While that trend has been underway for some time thanks to companies like Google, Facebook and ...

There is a gap between the technology industry and the fastest growing portion of today’s workforce and the workforce of the future: Latinos -- argue U.S. Representatives Loretta Sanchez (California) and Ruben Gallego (Arizona), both members of Congr...

The modern, average 12-year-old Madden NFL videogame player has actually visualized more plays than ‪any past real-life NFL Hall-of-Famer. And now, for the first time, we're seeing those videogame tactics show up on the field too. There's a "technolo...

When you're going for a board interview -- especially when it's your first board seat -- you're actually not supposed to go into it advocating for yourself and trying to convince people that you're a good operator, as you might in a job interview. So...

Apple has once again shown it absolutely dominates the high-end for smartphones, and no other company is likely to knock it from its perch in the near term, says a16z's Benedict Evans. But does it control the future of TV? Not yet.

Evans breaks do...

Disruption is such an overused buzzword. But the word itself does have meaning: As defined by the Oxford and Merriam-Webster dictionaries, it is a "disturbance...that interrupts an event, activity, or process" and that causes something "to be unable ...